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May 24, 2026Head & Face MedicineOpen Access

Impact of α-cyanoacrylate tissue adhesive on soft tissue healing at donor sites in free gingival graft surgery: a randomized controlled clinical trial

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Authors

TZTingyan ZengHYHaiyan YuXHXU Hong

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Overview

Randomized trial evaluates α-cyanoacrylate for improving healing in free gingival graft donor sites, suggesting an effective closure method.

Key Points

  • This study aims to evaluate the effect of α-cyanoacrylate tissue adhesive on wound healing and patient comfort at donor sites during free gingival graft surgery.
  • Sixty subjects undergoing FGG procedures were randomly allocated into three groups: sutures alone, sutures with CTA, and CTA alone.
  • Pain, analgesic consumption, wound closure time, and healing indices were assessed over 14 days.
  • Comparative analysis was performed for pain levels and healing parameters among the groups.
  • Group C (CTA alone) showed lower VAS pain scores than Group A on days 5 and 7 (P<0.05).
  • EHI scores were significantly better in Group C compared to Group A (P<0.05).
  • Wound closure time was significantly shorter in Group C than in Groups A and B (P<0.001), with comparable complication rates across groups.

Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/6a12958948a0ea1665671aadhttps://doi.org/10.1186/s13005-026-00627-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Application of a Flowable Composite as a Method for Donor Site Protection After Free Gingival Graft: A Comparative Analysis of Four Techniques2025 · 2 citations
  2. 2Stabilization of Free Soft Tissue Grafts Utilizing Biocompatible Cyanoacrylate: Case Series Reports2025
  3. 3Palatal donor site wound healing following mucogingival surgery using amnion‐chorion membrane: A randomized controlled clinical trial2026
  4. 4Chitosan‐based dressing for management of palatal donor site: A randomized clinical trial2024 · 3 citations
  5. 5Cyanoacrylate Tissue Adhesives in Peri‐Implant Surgery: A Case Report and Surgical Technique2025