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This study aims to identify factors influencing the acceptance of HPV vaccination among caregivers in eThekwini District.

May 24, 2026Open Access

Factors associated with acceptance of vaccination against human papillomavirus in eThekwini district of South Africa

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Cross-sectional study assesses factors influencing HPV vaccine acceptance in caregivers in eThekwini, indicating the need for targeted strategies.

This study aims to identify factors influencing the acceptance of HPV vaccination among caregivers in eThekwini District.
Conducted a cross-sectional study using stratified random sampling among caregivers of children aged 9-14 years.
Conducted interviews in April–May 2023.
Employed bivariate and multivariate logistic regression models for analysis.
Of 793 contacted individuals, 713 (89.9%) participated, with 93.5% accepting HPV vaccination.
Independent predictors of vaccine acceptance included awareness (aOR 5.22, 95% CI 2.01–13.56), confidence in vaccine safety (aOR 19.69, 95% CI 5.86–66.15), and endorsement by religious leaders (aOR 5.06, 95% CI 1.56–16.45).
Most participants (86.0%) were aware of the HPV vaccination program.

Human Sciences Research Council (2026) studied this question.

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Cross-sectional study assesses factors influencing HPV vaccine acceptance in caregivers in eThekwini, indicating the need for targeted strategies.