Experimental studies reveal the biological compatibility of ZIF-8 in A549 cells, suggesting its potential as an oxygen adsorption platform.
studies in A549 cells suggested acceptable short-term biological compatibility under the tested conditions. Overall, the results position ZIF-8 not as high-capacity systemic oxygen carrier, but as a mechanistically informative and biocompatible proof-of-concept platform for understanding oxygen adsorption, confinement, and localized release in MOF-based biomedical systems.
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Singh et al. (2026) studied this question.
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