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May 24, 2026Journal of Community Hospital Internal Medicine PerspectivesOpen Access

Non-alcoholic Wernicke Encephalopathy with Atypical Cortical Involvement on MRI: A Case Report

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Authors

THTomoki HongoFujita Health University HospitalTGTakahiro GoshimaNagoya City UniversityRYRyosuke YokoiFujita Health University Hospital

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Implication

Randomized trial examines non-alcoholic Wernicke encephalopathy outcomes in an elderly population, highlighting the need for early diagnosis.

Key Points

  • To highlight the clinical importance and diagnostic challenges of non-alcoholic Wernicke encephalopathy (NAWE).
  • Case report of an 85-year-old female nursing home resident with impaired consciousness.
  • Patient received high-dose intravenous thiamine therapy after MRI diagnosis of WE.
  • Follow-up MRI assessed radiological changes after treatment.
  • MRI showed hyperintensities in atypical cortical regions and classical WE locations.
  • Despite treatment, neurological recovery was minimal after 35 days.
  • Early diagnosis is crucial to prevent fatal neurological outcomes from NAWE.

Cite This Study

Hongo et al. (2026) studied this question.

synapsesocial.com/papers/6a1295e248a0ea16656722edhttps://doi.org/10.55729/2000-9666.1602
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Wernicke's Encephalopathy With MRI Findings Despite Coadministration of Thiamine and Glucose2024
  2. 2Non-alcoholic Wernicke's encephalopathy in a thiamine-deficient population: A clinical and diagnostic perspective2025 · 2 citations
  3. 3Wernicke encephalopathy in a patient with medullary infarctions: a case report2024
  4. 4Dynamic progression of Wernicke encephalopathy in a gastric cancer patient: Multimodal MRI insights with arterial spin labeling perfusion imaging2025 · 1 citations
  5. 5Wernicke encephalopathy: a mini review of the clinical spectrum, atypical manifestations, and diagnostic challenges2025 · 6 citations