Serum antithrombin III as an early predictive marker for post-hepatectomy liver failure: a prospective cohort study
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Key Points
This study aims to evaluate serum antithrombin III activity as an early predictive marker for post-hepatectomy liver failure (PHLF).
Prospective cohort study enrolling 151 patients at elevated risk of PHLF.
Measured antithrombin III activity preoperatively and on postoperative days 1, 2, 3, and 5.
Applied multivariable logistic regression to identify risk factors for PHLF.
PHLF occurred in 35 patients (23.2%).
Antithrombin III activity was significantly lower in the PHLF group at all assessed time points (P < 0.001).
A decline in ATIII activity ≥ 30% at POD 3 was associated with increased risk of PHLF (OR 3.04, P = 0.021).
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Implication
Prospective cohort study evaluates antithrombin III as an early marker for liver failure in at-risk patients, suggesting potential for timely intervention.