Demonstrates efficient conversion of C(sp3)–C(sp2) bonds to C(sp3)–F bonds in alkenes, highlighting a novel method for alkyl fluorides production.
Leveraging the abundance of alkenes, we report cleavage of the C(sp3)–C(sp2) bonds of alkenes as a route for radical fluorination. In this process, ozone leads to the creation of α-methoxyhydroperoxide intermediates from alkenes, with subsequent treatment with FeII and Selectfluor providing a variety of alkyl fluorides. The products are obtained under mild, aerobic reaction conditions within short reaction times.
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Dehnert et al. (2026) studied this question.
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