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May 24, 2026AntioxidantsOpen Access

Caloric Restriction Attenuates Gentamicin-Induced Acute Kidney Injury and Is Associated with Changes in Oxidative Stress and Mitochondrial DNA Damage

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Authors

XLXinyu LiaoNANadezda V. AndrianovaLZLjubava D. Zorova

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Overview

Randomized trial investigates caloric restriction reducing acute kidney injury in nephrotoxic settings, indicating a new preventive strategy.

Key Points

  • The research aimed to evaluate the effects of caloric restriction on gentamicin-induced acute kidney injury and its associated molecular mechanisms.
  • 5-week caloric restriction protocol during acute kidney injury induction.
  • Assessment of renal function, oxidative stress markers, and histological analysis.
  • Analyses included Western blotting and diagnostic assays.
  • Caloric restriction significantly reduced markers KIM-1 and NGAL, indicating improved renal function.
  • Decreased oxidative stress levels with reduced TBARS and protein carbonylation, along with improved glutathione metrics.
  • Reduced mitochondrial DNA lesions and lowered Bcl-XL/XS ratio pointed to decreased apoptosis and inflammation.

Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/6a12965848a0ea1665673109https://doi.org/10.3390/antiox15060653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Caloric Restriction Mimetic Hydroxycitrate Mitigates Acute Nephrotoxicity via Autophagy Activation and Oxidative Stress Reduction2026 · 2 citations
  2. 2Insights Into Regulated Cell Death Pathways in Gentamicin‐Induced Nephrotoxicity: Molecular Mechanisms and Future Perspectives2026
  3. 3ASSESSMENT OF THE NEPHROPROTECTIVE ACTIVITY OF OCIMUM GRATISSIMUM AGAINST GENTAMICIN-RELATED RENAL TOXICITY2025
  4. 4Histopathological Evidence of Resveratrol-Mediated Renal Protection Against Gentamicin Toxicity in Rats2026
  5. 5Nephroprotective Effect of a Combination of Probiotics, Tender Coconut Water, and Vitamin E in Gentamicin-Induced Acute Kidney Injury in Rats2025