Drug combo may extend ketamine's effect on suicidal ideation

Researchers are exploring ways to extend the short‐lived benefits of fast‐acting treatments for suicidal ideation (SI), a persistent challenge in managing major depressive disorder. Ketamine has been shown to rapidly reduce suicidal thoughts, but its effects often fade within days, leaving clinicians with few options to sustain improvement. New findings presented during the American Psychiatric Association's (APA's) annual meeting on May 18 suggest one possible strategy: pairing a single ketamine infusion with a follow‐on medication.