Construction of N,S-polyheterocyclic scaffolds via asymmetric [3+2] cycloaddition of benzothiazolium salts catalyzed by a chiral-at-metal rhodium complex

Highly efficient asymmetric [3+2] cycloaddition reactions of benzothiazolium salts with α,β-unsaturated 2-acyl imidazoles were achieved by a chiral-at-metal rhodium complex catalyst. The enantioenriched hydropyrrolo-thiazole derivatives bearing four contiguous tertiary stereocenters...