From static labels to dynamic trajectories: MASLD–MetALD–ALD as a dynamic continuum within the framework of steatotic liver disease

Lanlan Chen; Paul Horn; Frank Tacke

doi:10.1136/egastro-2026-100430

April 1, 2026eGastroenterologyOpen Access

From static labels to dynamic trajectories: MASLD–MetALD–ALD as a dynamic continuum within the framework of steatotic liver disease

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Key Points

To explore the relationships and dynamic transitions among different forms of steatotic liver disease.
Framework analysis of existing terminology relating to liver diseases.
Categorization of disease types based on metabolic and alcohol-related factors.
Identified MASLD, MetALD, and ALD as interrelated conditions within steatotic liver disease.
Proposed a continuum model to describe the progression and interactions between these liver disease types.

Implication

Framework demonstrating dynamic transitions in liver disease types, suggesting new understanding of their relationship.

Abstract

Introduction Steatotic liver disease (SLD) is an umbrella term mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD) and alcohol-associated liver disease (ALD).

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a12969048a0ea1665673721 https://doi.org/10.1136/egastro-2026-100430

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From static labels to dynamic trajectories: MASLD–MetALD–ALD as a dynamic continuum within the framework of steatotic liver disease

Key Points

Implication

Abstract

Discussion

Cite This Study

From static labels to dynamic trajectories: MASLD–MetALD–ALD as a dynamic continuum within the framework of steatotic liver disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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