Key result
Sheng Jing Decoction restores sperm concentration and motility in triptolide-treated mice via PI3K/Akt and MAPK pathways.
Why the study?
Does Sheng Jing Decoction improve sperm parameters and spermatogenesis in mice with triptolide-induced oligoasthenospermia?
Does Sheng Jing Decoction improve sperm parameters and spermatogenesis in mice with triptolide-induced oligoasthenospermia?
Sheng Jing Decoction shows potential as a complementary therapy for male infertility by improving sperm parameters and mitigating testicular toxicity in a mouse model.
May inform future human trials of Sheng Jing Decoction; leaves open clinical efficacy pending randomized evidence.
• Sheng Jing Decoction (SJD) ameliorates triptolide-induced oligoasthenospermia, restoring sperm concentration, motility, and spermatogenesis in mice. • The therapeutic effect of SJD is mediated through the concurrent modulation of the PI3K/Akt and MAPK signaling pathways. • SJD exerts multi-protective effects against testicular toxicity by mitigating apoptosis, oxidative stress, and inflammation. • This study provides a mechanistic foundation for the traditional use of SJD as a potential complementary therapy for male infertility.
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Gao et al. (2026) studied oligoasthenospermia. Sheng Jing Decoction (SJD) was evaluated on sperm concentration, motility, and spermatogenesis. Sheng Jing Decoction ameliorated triptolide-induced oligoasthenospermia in mice, restoring sperm concentration and motility by modulating PI3K/Akt and MAPK signaling pathways.
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