Perioperative and short-term oncological outcomes of laparoscopic versus open pancreaticoduodenectomy: an updated systematic review and meta-analysis of randomized controlled trials with GRADE evaluation
Randomized trial compares laparoscopic and open pancreatoduodenectomy outcomes in periampullary tumors, suggesting advantages for laparoscopic approach.
Key Points
This review aimed to evaluate and compare the perioperative and short-term oncological outcomes of laparoscopic pancreatoduodenectomy (LPD) and open pancreatoduodenectomy (OPD) in patients with periampullary tumors.
Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
Included seven RCTs comparing LPD and OPD
Evaluated outcomes like operative time, blood loss, length of stay, complications, and mortality.
LPD resulted in longer operative times (MD~50.90 min), but significantly less blood loss (MD−88.83 mL) and shorter hospital stays (MD−1.33 days).
Fewer transfusions were needed in the LPD group (RR 0.75).
No significant differences were found in 90-day mortality, overall complications, lymph node retrieval, or R0 resection rates.