Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 24, 2026ReproductionOpen Access

Protective Effects of Metformin and Vitamin C on Diabetes-Induced Testicular Dysfunction

View Full Paper
Ask AI
Bookmark
Share

Authors

SÖSüheyla Esra ÖzkoçerGEGamze Güney EskilerEKEce Konaç

Discussion

Loading...

Member takes

Overview

Randomized trial investigates combined metformin and vitamin C treatment effects on testicular health in diabetic mice, highlighting potential protective benefits.

Key Points

  • The study aims to explore the protective effects of combined metformin and vitamin C therapy against diabetes-induced testicular damage and dysfunction.
  • Experiment conducted on 36 C57BL mice divided into six treatment groups: Control, VitC, DM, DM+VitC, DM+Met, DM+VitC+Met.
  • Diabetes mellitus was induced using streptozotocin, followed by treatments with metformin (250 mg/kg/day) and vitamin C (100 mg/kg/day) for 40 days.
  • Sperm parameters, oxidative stress markers, gene expression of Dnah7 and Tomm20, and protein assays were evaluated using Muse™ Cell Analyzer, RT-PCR, Western blotting, and immunohistochemistry.
  • Combination therapy significantly increased sperm viability (p<0.01) and Johnsen score compared to monotherapy groups.
  • Testicular Dnah7 and Tomm20 mRNA expression levels were higher in the DM+VitC+Met group than in the DM group (p<0.05).
  • DM group showed increased hyperglycemia and decreased superoxide dismutase levels, indicating oxidative stress.

Cite This Study

Özkoçer et al. (2026) studied this question.

synapsesocial.com/papers/6a1296c748a0ea1665673d33https://doi.org/10.1093/reprod/xaag064
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Experimental animal models for diabetes and its related complications—a review2021 · 266 citations
  2. 2Overtime expression of plasma membrane and mitochondrial function markers associated with cell death in human spermatozoa exposed to nonphysiological levels of reactive oxygen species2020 · 5 citations
  3. 3Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice2020 · 58 citations
  4. 4Diabetes-induced male infertility: potential mechanisms and treatment options2024 · 96 citations
  5. 5Mechanisms of oxidative stress-induced sperm dysfunction2025 · 225 citations