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This research aims to investigate the toxic effects of Cu(OH)2 nanopesticide exposure in zebrafish using molecular and metabolomic approaches.

Integrated molecular and metabolomic assessment of copper hydroxide nanopesticide toxicity in zebrafish

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Randomized trial investigates toxic effects of copper hydroxide nanopesticides in zebrafish, highlighting ecological risks.

This research aims to investigate the toxic effects of Cu(OH)2 nanopesticide exposure in zebrafish using molecular and metabolomic approaches.
Zebrafish embryos exposed to sublethal Cu(OH)2 NP concentrations up to 96 hours post-fertilization.
Adults subjected to 14-day sub-chronic exposure to Cu(OH)2 NP.
Integrated analysis of gene expression related to copper homeostasis and metabolomic changes in response to exposure.
Cu(OH)2 NP exposure significantly altered gene expression involved in copper homeostasis and activated stress pathways. Effect sizes pertained to alterations in cox16, atp7a, ccs, and gclm.
Metabolomic analysis showed substantial reprogramming of energy metabolism and amino acid pathways after Cu(OH)2 NP exposure.
Hepatosomatic index (HSI) changes indicated disrupted energy balance and hepatic stress in adult zebrafish.

Aksakal et al. (2026) studied this question.

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