What question did this study set out to answer?

To determine how respiratory phase and breathing frequency influence sinus node inhibition in response to carotid baroreceptor stimulation in healthy humans.

July 1, 1980The Journal of PhysiologyOpen Access

Phase relationship between normal human respiration and baroreflex responsiveness.

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Why the study?

How do the phase of respiration and breathing frequency influence human sinus node responses to arterial baroreceptor stimulation?

Population

Normal human subjects

Comparison

Carotid baroreceptor stimulation via brief… vs Responses compared across different respiratory…

Authors

DEDwain L. EckbergGeneral Cardiology YKYemiserach KifleAddis Ababa University VRVerne L. RobertsNational Highway Traffic Safety Administration

Discussion

Member takes

Implication

Respiratory phase and rate warrant control during baroreflex testing; leaves open clinical translation and impact on risk stratification.

Key Points

To determine how respiratory phase and breathing frequency influence sinus node inhibition in response to carotid baroreceptor stimulation in healthy humans.
Applied brief (0.6 sec), moderate (30 mmHg) neck suction to stimulate carotid baroreceptors across early, mid, and late phases of inspiration and expiration during normal breathing.
Assessed baroreceptor responses during early inspiration and early expiration at paced breathing frequencies of 3, 6, 12, and 24 breaths/min.
Sinus node inhibition was minimal during early to mid inspiration and late expiration, reaching peak levels when stimuli were delivered during late inspiration and early expiration.
Expiratory baroreflex responses were significantly greater than inspiratory responses at 3, 6, and 12 breaths/min, whereas differential responsiveness was lost at 24 breaths/min.

Structured PICO

How do the phase of respiration and breathing frequency influence human sinus node responses to arterial baroreceptor stimulation?

Population

Normal human subjects

Intervention

Carotid baroreceptor stimulation via brief (0.6 sec), moderate (30 mmHg) neck suction during various phases of respiration and breathing rates

Comparator

Responses compared across different respiratory phases (early, mid, late inspiration/expiration) and breathing rates (3, 6, 12, 24 breaths/min)

Outcome

Sinus node inhibition (baroreflex responsiveness)surrogate

Human baroreflex responsiveness oscillates continuously during normal respiration, with maximum responsiveness during late inspiration and early expiration, a differential that is lost at rapid breathing rates.

Cite This Study

Eckberg et al. (1980) studied this question.

synapsesocial.com/papers/6a129ba15a4f3a9db9a3f69d https://doi.org/10.1113/jphysiol.1980.sp013338

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Phase relationship between normal human respiration and baroreflex responsiveness.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Phase relationship between normal human respiration and baroreflex responsiveness.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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