Key result
Transdermal glyceryl trinitrate patches showed changes in bioavailability over 24 hours, with clinical tolerance developing despite maintained arterial vasodilating effects.
Why the study?
How do changes in transdermal glyceryl trinitrate (GTN) bioavailability relate to clinical efficacy and the development of nitrate tolerance over 24 hours?
Population
Angina patients and rabbit models
Design
Other
Follow-up
24 hours
Authors
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Tolerance to transdermal GTN develops within 24 hours despite maintained arterial effects; leaves open venous counterregulation as a key mechanism for further study.
How do changes in transdermal glyceryl trinitrate (GTN) bioavailability relate to clinical efficacy and the development of nitrate tolerance over 24 hours?
Clinical nitrate tolerance to transdermal GTN patches develops within 24 hours despite maintained arterial vasodilation, likely driven by venous counterregulatory mechanisms.
Tor Ole Klemsdal (1997) studied Angina. Glyceryl trinitrate (GTN) patches was evaluated on GTN bioavailability and clinical efficacy. Transdermal glyceryl trinitrate patches showed changes in bioavailability over 24 hours, with clinical tolerance developing despite maintained arterial vasodilating effects.
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