Key result
Gestational diabetes mellitus was associated with septal hypertrophy (≥6 mm) in 40% of exposed newborns and impaired diastolic function, but these changes were not associated with ADMA levels.
Why the study?
Are asymmetric dimethylarginine (ADMA) concentrations associated with ventricular function in term infants of mothers with gestational diabetes?
Population
50 term newborns (25 born to mothers with gestational diabetes mellitus and 25 healthy controls)
Comparison
Maternal gestational diabetes mellitus (exposure) vs Mothers with normal general health status
Design
Cohort
Follow-up
3 months
Authors
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GDM-related neonatal cardiac changes warrant no ADMA assessment or therapy; leaves open alternative mechanisms for study.
Observational (n=50)
Are asymmetric dimethylarginine (ADMA) concentrations associated with ventricular function in term infants of mothers with gestational diabetes?
Newborn cardiac wall thickness is increased and diastolic function impaired in pregnancies complicated by GDM, but this is not associated with ADMA levels.
Arslan et al. (2013) conducted an observational in Gestational diabetes mellitus (n=50). Gestational diabetes mellitus exposure vs. Normal general health status was evaluated on Ventricular function and ADMA concentrations. Gestational diabetes mellitus was associated with septal hypertrophy (≥6 mm) in 40% of exposed newborns and impaired diastolic function, but these changes were not associated with ADMA levels.
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