What is the clinical evidence from this study?

Study design: Other. Intervention: Carvedilol vs. Baseline and post-L-NAME (NOS inhibitor). Primary outcome: Mean arterial pressure (p=<.001).

What does this research mean for the field?

The blood pressure-lowering effect of carvedilol is partially dependent on the endogenous production of nitric oxide, as evidenced by the abolition of its hemodynamic effects following nitric oxide synthase inhibition. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 31, 2006American Journal of Hypertension

Carvedilol Action Is Dependent on Endogenous Production of Nitric Oxide

Q: What are the key findings of this study?

Carvedilol significantly decreased mean arterial pressure (from 126.6 to 75.9 mm Hg, P<.001) and increased NO levels, effects that were abolished by NOS inhibition with L-NAME.

Q: What does this research mean for the field?

The blood pressure-lowering effect of carvedilol is partially dependent on the endogenous production of nitric oxide, as evidenced by the abolition of its hemodynamic effects following nitric oxide synthase inhibition. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Carvedilol significantly decreased mean arterial pressure (from 126.6 to 75.9 mm Hg, P<.001) and increased NO levels, effects that were abolished by NOS inhibition with L-NAME.

Why the study?

Does carvedilol decrease blood pressure via endogenous nitric oxide production in male Wistar rats?

Population

Male Wistar rats, 9 weeks old, anesthetized with an intraperitoneal injection of sodium pentobarbital.

Comparison

Carvedilol evaluated before and after NO… vs Baseline measurements before carvedilol, and…

Design

Preclinical

Authors

RARicardo A. AfonsoUniversity of Lisbon RPRita S. PatarrãoUniversity of Lisbon MMMaria Paula MacedoAssociacao Protectora dos Diabeticos de Portugal

Discussion

Member takes

Implication

Suggests NO mediation of carvedilol BP effects in rats; leaves open human translation.

Structured PICO

Does carvedilol decrease blood pressure via endogenous nitric oxide production in male Wistar rats?

Population

Male Wistar rats (n = 22), 9 weeks old, anesthetized with an intraperitoneal injection of sodium pentobarbital.

Intervention

Carvedilol (1 mg/kg, intravenously [iv]) evaluated before and after NO synthase (NOS) inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME, 5 mg/kg, iv).

Comparator

Baseline measurements before carvedilol, and carvedilol effects after L-NAME administration.

Outcome

Mean arterial pressure and arterial NO levels.surrogate

Main Result

p-value: p=<.001

The hemodynamic and blood pressure-lowering effects of carvedilol are partially dependent on the endogenous production of nitric oxide.

Cite This Study

Afonso et al. (2006) studied this question. Carvedilol vs. Baseline and post-L-NAME (NOS inhibitor) was evaluated on Mean arterial pressure (p=<.001). Carvedilol significantly decreased mean arterial pressure (from 126.6 to 75.9 mm Hg, P<.001) and increased NO levels, effects that were abolished by NOS inhibition with L-NAME.

synapsesocial.com/papers/6a129ebc5a4f3a9db9a3fcfc https://doi.org/10.1016/j.amjhyper.2005.11.011

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Carvedilol Action Is Dependent on Endogenous Production of Nitric Oxide

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Carvedilol Action Is Dependent on Endogenous Production of Nitric Oxide

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider