Key result
Combined cDTI and DENSE shows transmural myofiber strain is more spatially uniform than circumferential strain.
Why the study?
Myofiber strain is expected to be spatially uniform in healthy populations and a prime candidate for evaluating cardiomyocyte contractility, motivating a new, efficient pipeline combining cDTI and DENSE to estimate it in vivo.
Can a pipeline combining cDTI and DENSE MRI data efficiently measure in vivo myofiber strain in healthy humans?
Cross-Sectional (n=30)
Can a pipeline combining cDTI and DENSE MRI data efficiently measure in vivo myofiber strain in healthy humans?
Absolute Event Rate: -0.14% vs -0.18%
p-value: p=<.001
A novel MRI pipeline combining cDTI and DENSE data can efficiently measure in vivo myofiber strain, demonstrating its transmural uniformity in healthy humans.
Supports feasibility of cDTI-DENSE pipeline for myofiber strain in healthy hearts; leaves open validation and clinical utility in disease.
Purpose Myofiber strain, E ff , is a mechanistically relevant metric of cardiac cell shortening and is expected to be spatially uniform in healthy populations, making it a prime candidate for the evaluation of local cardiomyocyte contractility. In this study, a new, efficient pipeline was proposed to combine microstructural cDTI and functional DENSE data in order to estimate E ff in vivo. Methods Thirty healthy volunteers were scanned with three long‐axis (LA) and three short‐axis (SA) DENSE slices using 2D displacement encoding and one SA slice of cDTI. The total acquisition time was 11 minutes ± 3 minutes across volunteers. The pipeline first generates 3D SA displacements from all DENSE slices which are then combined with cDTI data to generate a cine of myofiber orientations and compute E ff . The precision of the post‐processing pipeline was assessed using a computational phantom study. Transmural myofiber strain was compared to circumferential strain, E cc , in healthy volunteers using a Wilcoxon sign rank test. Results In vivo, computed E ff was found uniform transmurally compared to E cc (−0.14[−0.15, −0.12] vs −0.18 [−0.20, −0.16], P < .001, −0.14 [−0.16, −0.12] vs −0.16 [−0.17, −0.13], P < .001 and −0.14 [−0.16, −0.12] vs E cc_C = −0.14 [−0.15, −0.11], P = .002, E ff_C vs E cc_C in the endo, mid, and epi layers, respectively). Conclusion We demonstrate that it is possible to measure in vivo myofiber strain in a healthy human population in 10 minutes per subject. Myofiber strain was observed to be spatially uniform in healthy volunteers making it a potential biomarker for the evaluation of local cardiomyocyte contractility in assessing cardiovascular dysfunction.
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Moulin et al. (2021) conducted a cross-sectional in Healthy (n=30). Combined microstructural cDTI and functional DENSE imaging vs. Circumferential strain (Ecc) was evaluated on Transmural myofiber strain (Eff) compared to circumferential strain (Ecc) in the endocardial layer (p=<.001). In vivo myofiber strain measured via combined cDTI and DENSE was spatially uniform transmurally compared to circumferential strain in healthy volunteers (endo layer -0.14 vs -0.18; P<0.001).
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