High Doses of Digitalis Increase the Myocardial Production of Proinflammatory Cytokines and Worsen Myocardial Injury in Viral Myocarditis
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Key result
High-dose digoxin (10 mg/kg/day) significantly increased 14-day mortality and worsened myocardial necrosis and cellular infiltration in a murine model of viral myocarditis.
Why the study?
Does digoxin improve survival and reduce myocardial injury in a murine model of viral myocarditis?
Population
Four-week-old inbred male DBA/2 mice inoculated intraperitoneally with encephalomyocarditis virus to induce…
Comparison
Digoxin 0.1, 1, or 10 mg/kg administered orally… vs Vehicle (water) administered orally once daily.
Design
Preclinical, Histological grading by 2 blinded observers
Follow-up
14 days
Authors
Discussion
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Implication
High-dose digoxin worsened murine viral myocarditis; hypothesis-generating for human use and should not yet change practice.
Structured PICO
Does digoxin improve survival and reduce myocardial injury in a murine model of viral myocarditis?
P
Population
Four-week-old inbred male DBA/2 mice inoculated intraperitoneally with encephalomyocarditis virus (EMCV) to induce viral myocarditis.
I
Intervention
Digoxin 0.1, 1, or 10 mg/kg administered orally once daily from the day of virus inoculation.
C
Comparator
Vehicle (water) administered orally once daily.
O
Outcome
14-day mortality/survivalhard clinical
High-dose digoxin worsens survival and increases myocardial inflammation in a murine model of viral myocarditis, suggesting it should be avoided in patients with heart failure due to viral myocarditis.
Cite This Study
Matsumori et al. (1999) studied Viral myocarditis. Digoxin vs. Control group was evaluated on 14-day mortality, myocardial necrosis, cellular infiltration, and cytokine production. High-dose digoxin (10 mg/kg/day) significantly increased 14-day mortality and worsened myocardial necrosis and cellular infiltration in a murine model of viral myocarditis.
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