A higher triglyceride to HDL-cholesterol ratio was independently associated with increased arterial stiffness in adolescents and young adults, with the effect being especially strong in obese subjects.
Cross-Sectional (n=893)
No
Does a higher TG/HDL-C ratio predict increased arterial stiffness in children, adolescents, and young adults?
The TG/HDL-C ratio is an independent predictor of arterial stiffness in youth, suggesting its potential utility as a simple biomarker to identify young individuals requiring early intervention to prevent atherosclerotic cardiovascular disease.
p-value: p=<0.03
BACKGROUND AND OBJECTIVE: Lipid levels are linked to early atherosclerosis. Risk stratification may be improved by using triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), which relates to arterial stiffness in adults. We tested whether TG/HDL-C was an independent predictor of arterial stiffness in youth. METHODS: Subjects 10 to 26 years old (mean 18.9 years, 39% male, 56% non-Caucasian, n = 893) had laboratory, anthropometric, blood pressure, and arterial stiffness data collected (brachial distensibility, augmentation index, carotid-femoral pulse-wave velocity). Subjects were stratified into tertiles of TG/HDL-C (low, n = 227; mid, n = 288; high, n = 379). RESULTS: There was a progressive rise in cardiovascular (CV) risk factors and arterial stiffness across TG/HDL-C ratio. The high TG/HDL-C ratio group had the stiffest vessels (all P < .03 by analysis of variance). TG/HDL-C as a continuous variable was an independent determinant of brachial distensibility in CV risk factor adjusted model and for carotid-femoral pulse-wave velocity in obese subjects, with trend for higher augmentation index. CONCLUSIONS: TG/HDL-C, an estimate of small, dense low-density lipoprotein cholesterol, is an independent determinant of arterial stiffness in adolescents and young adults, especially in obese youth. These data suggest that use of TG/HDL-C may be helpful in identifying young adults requiring aggressive intervention to prevent atherosclerotic CV diseases.
Urbina et al. (Tue,) conducted a cross-sectional in Healthy children, adolescents, and young adults (n=893). High Triglyceride to HDL-C Ratio vs. Low Triglyceride to HDL-C Ratio was evaluated on Arterial stiffness (brachial distensibility, augmentation index, carotid-femoral pulse-wave velocity) (p=<0.03). A higher triglyceride to HDL-cholesterol ratio was independently associated with increased arterial stiffness in adolescents and young adults, with the effect being especially strong in obese subjects.