Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1987CirculationOpen Access

Action potential duration at -60 mV was significantly longer during centrifugal propagation compared to longitudinal propagation, with further shortening during transverse propagation and the shortest duration during collision.

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated canine ventricular muscles (25 x 25 mm preparations with nearly uniform fiber orientation)

Comparison

Different activation sequences vs Comparisons between different activation sequences

Design

Preclinical

Authors

TOToshiyuki OsakaIKI. KodamaNTNobuo Tsuboi

Discussion

Loading...

Member takes

Overview

May modulate reentry risk via refractoriness inhomogeneity; hypothesis-generating in animal models, human relevance remains open.

Structured PICO

P
Population
Isolated canine ventricular muscles (25 x 25 mm preparations with nearly uniform fiber orientation)
I
Intervention
Different activation sequences (centrifugal, longitudinal, transverse propagation, and collision of wavefronts)
C
Comparator
Comparisons between different activation sequences
O
Outcome
Action potential duration at -60 mV (APD-60 mV)surrogate

Activation sequence and anisotropic cellular geometry significantly alter action potential duration, creating spatial inhomogeneity in refractoriness that facilitates reentrant arrhythmias.

Cite This Study

Osaka et al. (1987) studied this question.

synapsesocial.com/papers/6a12aaf7b8b0b51fb9a40de1https://doi.org/10.1161/01.cir.76.1.226
View Full Paper
Ask AI
Bookmark
Share