What question did this study set out to answer?

To demonstrate the bias introduced when assessing factors linked to age at natural menopause in a study population selected using restricted time-since-menopause criteria.

January 1, 1995Menopause The Journal of The North American Menopause Society

Age at Menopause in Women Participating in the Postmenopausal Estrogen/Progestins Interventions (PEPI) Trial

View Full Paper

Ask AI

Bookmark

Authors

GGGail A. GreendaleUniversity of California, Los Angeles PHPatricia E. HoganHogan Lovells (United States)DKDonna Kritz‐SilversteinUniversity of California, San Diego

Discussion

Member takes

Implication

Randomized trial reveals artificial associations with age at menopause in postmenopausal women, highlighting significant selection bias from restrictive trial entry criteria.

Key Points

To demonstrate the bias introduced when assessing factors linked to age at natural menopause in a study population selected using restricted time-since-menopause criteria.
Cross-sectional evaluation of baseline data from the Postmenopausal Estrogen/Progestins Interventions (PEPI) randomized clinical trial.
Included 601 postmenopausal women without a hysterectomy, aged 45 to 64 years, who experienced menopause between 1 and 10 years prior to entry.
Evaluated correlations between self-reported menopausal age and lifestyle, anthropometric, and clinical factors using bivariate analyses and 5-year age-stratified models.
Mean chronological age was 56.2 years, mean age at menopause was 51.0 years, and chronological age strongly correlated with age at menopause (r = 0.74, p = 0.0001).
Bivariate analyses showed younger menopause was associated with smoking, past oral contraceptive use, and thigh girth, whereas later menopause was associated with higher parity, waist-hip ratio, and systolic blood pressure.
Stratification by 5-year chronological age intervals eliminated all statistically significant associations, demonstrating that the initial findings were artifacts of restricted sampling criteria.

Cite This Study

Greendale et al. (1995) studied this question.

synapsesocial.com/papers/6a12aef019b8e19607351fe2 https://doi.org/10.1097/00042192-199502010-00005

View Full Paper

Ask AI

Bookmark

January 1, 1995Menopause The Journal of The North American Menopause Society

Age at Menopause in Women Participating in the Postmenopausal Estrogen/Progestins Interventions (PEPI) Trial

View Full Paper

Ask AI

Bookmark

Authors

GGGail A. GreendaleUniversity of California, Los Angeles PHPatricia E. HoganHogan Lovells (United States)DKDonna Kritz‐SilversteinUniversity of California, San Diego

Discussion

Member takes

Implication

Randomized trial reveals artificial associations with age at menopause in postmenopausal women, highlighting significant selection bias from restrictive trial entry criteria.

Key Points

To demonstrate the bias introduced when assessing factors linked to age at natural menopause in a study population selected using restricted time-since-menopause criteria.
Cross-sectional evaluation of baseline data from the Postmenopausal Estrogen/Progestins Interventions (PEPI) randomized clinical trial.
Included 601 postmenopausal women without a hysterectomy, aged 45 to 64 years, who experienced menopause between 1 and 10 years prior to entry.
Evaluated correlations between self-reported menopausal age and lifestyle, anthropometric, and clinical factors using bivariate analyses and 5-year age-stratified models.
Mean chronological age was 56.2 years, mean age at menopause was 51.0 years, and chronological age strongly correlated with age at menopause (r = 0.74, p = 0.0001).
Bivariate analyses showed younger menopause was associated with smoking, past oral contraceptive use, and thigh girth, whereas later menopause was associated with higher parity, waist-hip ratio, and systolic blood pressure.
Stratification by 5-year chronological age intervals eliminated all statistically significant associations, demonstrating that the initial findings were artifacts of restricted sampling criteria.

Cite This Study

Greendale et al. (1995) studied this question.

synapsesocial.com/papers/6a12aef019b8e19607351fe2 https://doi.org/10.1097/00042192-199502010-00005

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark