Key result
Obesity may accelerate cardiac aging and worsen outcomes in the elderly via energy metabolism dysfunction.
Why the study?
With the escalating prevalence of obesity and the aging population increasing cardiovascular diseases, investigating the underlying mechanisms linking obesity, cardiac energy metabolism, and aging is crucial.
Obesity may accelerate the process of cardiac aging through mechanisms involving metabolic inflexibility, altered substrate utilization, and mitochondrial dysfunction.
Answers are grounded in this paper and cite their sources.
Does not support practice changes in obese elderly; leaves open causal metabolic links to cardiac aging for prospective testing.
Obesity and aging are well-established risk factors for a range of diseases, including cardiovascular diseases and type 2 diabetes. Given the escalating prevalence of obesity, the aging population, and the subsequent increase in cardiovascular diseases, it is crucial to investigate the underlying mechanisms involved. Both aging and obesity have profound effects on the energy metabolism through various mechanisms, including metabolic inflexibility, altered substrate utilization for energy production, deregulated nutrient sensing, and mitochondrial dysfunction. In this review, we aim to present and discuss the hypothesis that obesity, due to its similarity in changes observed in the aging heart, may accelerate the process of cardiac aging and exacerbate the clinical outcomes of elderly individuals with obesity.
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Owesny et al. (2023) conducted a review in Obesity and aging (cardiovascular diseases). Obesity may accelerate the process of cardiac aging and exacerbate clinical outcomes in elderly individuals through shared mechanisms of energy metabolism dysfunction.
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