Key result
Root mean square (RMS) based QRS-widths obtained from endocardial and epicardial surfaces showed no statistically significant differences compared with true total ventricular activation time.
Why the study?
Does RMS-based QRS width accurately represent true total ventricular activation time in isolated canine hearts?
Does RMS-based QRS width accurately represent true total ventricular activation time in isolated canine hearts?
RMS-based QRS width techniques provide accurate measures of total ventricular activation time, which may have implications for optimizing cardiac resynchronization therapy.
RMS QRS width accurately measures activation time in canine hearts; leaves open translation to human CRT optimization.
The purpose of this study was to determine improved measures of total ventricular activation time for the diagnosis and treatment of patients undergoing cardiac resynchronization therapy (CRT). This work investigates the accuracy of a root mean square (RMS) based QRS width computed from unipolar electrograms (EGs) measured in heart for representing true total ventricular activation time (TVAT). The study also investigated the use subsets of EGs obtained from the endocardial and epicardial surfaces as indicators of TVAT. Transmural needle electrodes (96) were used to obtain 960 EGs from six normal isolated canine hearts. RMS-based QRS-widths from the endocardial and epicardial surfaces and volume were compared to the TVAT measured from all 960 EGs. No statistically significant differences were found in RMS-based QRS-widths obtained from all three sets of electrograms when compared with true TVAT. Activation times obtained from endocardial and epicardial surfaces were found to be poor indicators of true TVAT. The results support the use of RMS techniques for providing more accurate measures of TVAT.
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Sutherland et al. (2006) studied Cardiac resynchronization therapy (CRT) (n=6). Root mean square (RMS) based QRS width computed from unipolar electrograms vs. True total ventricular activation time (TVAT) was evaluated on Accuracy of RMS-based QRS width compared to true TVAT. Root mean square (RMS) based QRS-widths obtained from endocardial and epicardial surfaces showed no statistically significant differences compared with true total ventricular activation time.
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