What question did this study set out to answer?

To evaluate methods for estimating the transmural depth of origin of ventricular activation directly from cardiac surface electrograms.

October 1, 1990CirculationOpen Access

Determination of transmural location of onset of activation from cardiac surface electrograms.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Ventricular activation (n=8). Intervention: Methods of estimating depth of origin of ventricular activation. Primary outcome: Correlation between depth of stimulation and evaluated indexes (gradients of isochrones, QRS area, t(ee)-t(rmso) interval) (r ≥0.985).

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Key result

Methods estimating the depth of origin of ventricular activation from cardiac surface electrograms correlated highly with the depth of stimulation (correlation coefficients ≥0.985).

Authors

MBMary Jo BurgessConway Regional Health System RLRobert L. LuxRonald Reagan UCLA Medical Center PEP.R. ErshlerUniversity of Utah

Discussion

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Implication

Provides preliminary support for surface electrogram depth estimation; hypothesis-generating and requires prospective validation before clinical use.

Key Points

To evaluate methods for estimating the transmural depth of origin of ventricular activation directly from cardiac surface electrograms.
Paced the left ventricular wall at various transmural depths in eight dogs using multielectrode needle arrays inserted across four to six locations.
Simultaneously recorded electrical signals from 64 unipolar cardiac surface electrodes during each pacing sequence.
Evaluated four indices: average and maximum activation isochrone gradients around earliest activation, QRS area at the earliest site, and total activation intervals.
Correlation coefficients between pacing stimulation depth and the isochrone gradients, QRS area, and earliest activation intervals were 0.985 or higher.
Surface activation isochrone gradients provided a reliable method for mapping the three-dimensional depth of arrhythmia origin for surgical ablation.

PICO

Population

Ventricular activation (n=8)

Intervention / Comparator

Methods of estimating depth of origin of ventricular activation

Primary Outcome

Correlation between depth of stimulation and evaluated indexes (gradients of isochrones, QRS area, t(ee)-t(rmso) interval) — r ≥0.985

Main Result

Effect estimate: r ≥0.985

Cite This Study

Burgess et al. (1990) studied Ventricular activation (n=8). Methods of estimating depth of origin of ventricular activation was evaluated on Correlation between depth of stimulation and evaluated indexes (gradients of isochrones, QRS area, t(ee)-t(rmso) interval) (r ≥0.985). Methods estimating the depth of origin of ventricular activation from cardiac surface electrograms correlated highly with the depth of stimulation (correlation coefficients ≥0.985).

synapsesocial.com/papers/6a161a4a8ec422d49e949ec0 https://doi.org/10.1161/01.cir.82.4.1335

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Implication

Provides preliminary support for surface electrogram depth estimation; hypothesis-generating and requires prospective validation before clinical use.

Determination of transmural location of onset of activation from cardiac surface electrograms.

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

Determination of transmural location of onset of activation from cardiac surface electrograms.

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

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