What does this research mean for the field?

Q: What does this research mean for the field?

Prior myocardial infarction significantly increases the risk of flecainide-induced ventricular proarrhythmia, which is primarily driven by anisotropic reentry around a localized arc of rate-dependent transverse conduction block. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1995Circulation

Determinants and Mechanisms of Flecainide-Induced Promotion of Ventricular Tachycardia in Anesthetized Dogs

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Why the study?

Does prior myocardial infarction increase the risk of flecainide-induced ventricular proarrhythmia in a canine model?

Structured PICO

Does prior myocardial infarction increase the risk of flecainide-induced ventricular proarrhythmia in a canine model?

Population

32 anesthetized dogs (13 healthy dogs and 19 dogs with 72-hour-old myocardial infarctions)

Intervention

Successive loading and maintenance infusions of flecainide until ventricular tachyarrhythmia or death occurred

Comparator

Healthy dogs (for comparing MI vs healthy) and control conditions (baseline before flecainide)

Outcome

Ventricular proarrhythmia (reproducible ventricular tachycardia absent under control conditions and occurring in the presence of flecainide)safety

Prior myocardial infarction strongly predisposes to flecainide-induced ventricular proarrhythmia, likely driven by anisotropic reentry around a localized arc of rate-dependent transverse conduction block.

Discussion

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Implication

May warrant caution with flecainide post-MI; extends canine proarrhythmia data but leaves open clinical translation.

Cite This Study

Ranger et al. (1995) studied this question.

synapsesocial.com/papers/6a12b4ed2a15bedf5103a46d https://doi.org/10.1161/01.cir.92.5.1300

Topics

Ventricular arrhythmias

View Full Paper

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Bookmark

Determinants and Mechanisms of Flecainide-Induced Promotion of Ventricular Tachycardia in Anesthetized Dogs

Structured PICO

Discussion

Implication

Cite This Study

Topics

Determinants and Mechanisms of Flecainide-Induced Promotion of Ventricular Tachycardia in Anesthetized Dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider