Key result
Female patients with aSAH show a ~31% higher absolute prevalence of ICA aneurysms than males.
Why the study?
Gender-related variations in aneurysm characteristics may influence clinical presentation, imaging findings, and management strategies in patients with aneurysmal subarachnoid hemorrhage.
Are there gender-based differences in aneurysm characteristics among patients with aneurysmal subarachnoid hemorrhage?
Cross-Sectional (n=111)
No
Are there gender-based differences in aneurysm characteristics among patients with aneurysmal subarachnoid hemorrhage?
Significant gender-based differences exist in aSAH patients, with females presenting at an older age with smaller, more frequently multiple, and ICA-located aneurysms, whereas males present younger with larger, more frequently fusiform, and ACA-located aneurysms.
Answers are grounded in this paper and cite their sources.
Sex differences in ICA aneurysm prevalence may inform sex-stratified evaluation in aSAH; leaves open impact on outcomes or management.
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurovascular emergency. Gender-related variations in aneurysm characteristics may influence clinical presentation, imaging findings, and management strategies. This study aimed to evaluate the frequency distribution and gender-based differences in aneurysm characteristics among patients with aSAH using multidetector computed tomography (MDCT) angiography. METHODS: This cross-sectional observational study was conducted in the Department of Radiodiagnosis, Sriram Chandra Bhanj Medical College and Hospital (SCBMCH), Cuttack, a tertiary care hospital in the eastern region of India. A total of 111 patients with MDCT angiography-confirmed aSAH were included. Aneurysm features such as size, shape, multiplicity, and location were assessed. Statistical analysis was performed using the Chi-squared test, Fisher's exact test, t-test, and Z-test, with a p-value of <0.05 considered statistically significant. RESULTS: Of the 111 patients, 73 were female and 38 male (female-to-male ratio: 1.9:1). Female patients were significantly older than male patients (mean age: 56.11 versus 49.95 years; p = 0.020). Multiple aneurysms were more common in female patients (19.18%) than in male patients (5.3%; p = 0.0518). Aneurysms < 6 mm were more frequent in female patients (66.67%), while larger aneurysms (>10 mm) were more prevalent in male patients (20%; p = 0.0285). Fusiform aneurysms were significantly more common in male patients (15% versus 3.5%; p = 0.0273). Anterior circulation was involved in 92.22% of cases. Internal carotid artery (ICA) aneurysms predominated in female patients (48.27%), whereas anterior cerebral artery (ACA) aneurysms were more common in male patients (42.5%; p = 0.035). CONCLUSION: Gender-based differences in aneurysm characteristics, including age at presentation, size, shape, and location, were evident in patients with aSAH. Awareness of these variations is essential for accurate diagnosis, individualized risk assessment, and development of tailored management strategies.
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Tripathy et al. (2025) conducted a cross-sectional in Aneurysmal subarachnoid hemorrhage (n=111). Female gender vs. Male gender was evaluated on Internal carotid artery (ICA) aneurysm prevalence (p=<0.001). Female patients with aneurysmal subarachnoid hemorrhage had a significantly higher prevalence of internal carotid artery aneurysms (48.27% vs 17.5%) compared to male patients.
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