What question did this study set out to answer?

Summarize the molecular mechanisms linking the senescence-associated secretory phenotype (SASP) to atherosclerosis and evaluate potential SASP-targeted therapies for aging populations.

May 31, 2022Cell & BioscienceOpen Access

The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

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Authors

YSYu SunTongji University XWXia WangQingdao University TLTianwei LiuQingdao University

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Implication

Review reveals how senescence-associated secretory phenotype drives arterial disease during aging, highlighting senescent cell targeting as a promising cardiovascular therapy.

Key Points

Summarize the molecular mechanisms linking the senescence-associated secretory phenotype (SASP) to atherosclerosis and evaluate potential SASP-targeted therapies for aging populations.
Synthesized molecular and cellular evidence detailing SASP characteristics and regulation across diverse senescent vascular cell types.
Evaluated emerging therapeutic strategies aimed at clearing senescent cells and disrupting SASP signaling pathways.
The SASP directly accelerates atherosclerosis progression across various senescent cell lineages by inducing persistent vascular inflammation and immune dysfunction.
Secreted factors spread senescence signals paracrinally to adjacent vascular cells, exacerbating structural arterial degradation.
Targeted elimination of senescent cells or selective inhibition of SASP regulatory pathways shows promise for attenuating the cardiovascular burden of aging.

Cite This Study

Sun et al. (2022) studied this question.

synapsesocial.com/papers/6a12b6bbc031bb6829a7283b https://doi.org/10.1186/s13578-022-00815-5

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Implication

Review reveals how senescence-associated secretory phenotype drives arterial disease during aging, highlighting senescent cell targeting as a promising cardiovascular therapy.

The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

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