Key result
Relative peak VO2 was the strongest predictor of cardiac-related re-hospitalization within two years in patients with heart failure with reduced ejection fraction (OR 0.678).
Why the study?
This study examined the influence of maximal aerobic capacity on two-year cardiac-related re-hospitalization in Korean patients with heart failure with reduced ejection fraction.
Cohort (n=95)
No
Maximal aerobic capacity, specifically relative peak VO2, is a strong independent predictor of 2-year cardiac-related re-hospitalization in patients with HFrEF.
May aid re-hospitalization risk stratification in HFrEF; leaves open prospective validation for guiding therapy.
Purpose: This study examined the influence of the maximal aerobic capacity on the two-year cardiac-related re-hospitalization in patients with heart failure with a reduced ejection fraction (HFrEF) in Korean society. Methods: The maximal aerobic capacity of the study population (n= 95, male 63%) was evaluated using a cardiopulmonary exercise (CPX) testing system. Each patient was followed up for two years to divide the HFrEF patients into two groups according to cardiac-related re-hospitalization: re-hospitalization (RH) group (n= 29, 30%) and no re-hospitalization (NRH) group (n= 66, 70%). Results: The relative peak VO2 (mL/kg/min, p< 0.001), exercise duration (p< 0.001), respiratory exchange ratio (VCO2/VO2, p= 0.001), systolic blood pressure (SBP) reserve (p= 0.004), heart rate (HR) reserve (p= 0.007), SBP max (p= 0.02), and HR max (p= 0.039) were significantly lower in the RH group than the NRH group during the CPX test. On the other hand, the ventilatory efficiency (VE/VCO2 slope, p= 0.02) and age (p= 0.022) were significantly higher in the RH group than in the NRH group. In binary logistic regression analysis, the relative peak VO2 (p= 0.001, Wald Chi-square 10.137) was the strongest predictive factor on cardiac-related re-hospitalization, which was followed by VCO2/VO2 (p= 0.019, Wald Chi-square 5.54). On the other hand, age (p= 0.063, Wald Chi-square 3.445) did not have a significant influence on cardiac related re-hospitalization.
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Ryu et al. (2019) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=95). Relative peak VO2 (Maximal aerobic capacity) was evaluated on Cardiac-related re-hospitalization within 2 years (OR 0.678, 95% CI 0.534-0.861, p=0.001). Relative peak VO2 was the strongest predictor of cardiac-related re-hospitalization within two years in patients with heart failure with reduced ejection fraction (OR 0.678).
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