Key result
Oral anticoagulant prescribing in T2D increases ~50%, shifting toward DOACs.
Why the study?
To evaluate oral anticoagulant prescribing trends in type 2 diabetes mellitus in the UK from 2001 to 2015.
What are the trends in oral anticoagulant prescribing among individuals with type 2 diabetes mellitus in the UK from 2001 to 2015?
Cross-Sectional (n=361,635)
What are the trends in oral anticoagulant prescribing among individuals with type 2 diabetes mellitus in the UK from 2001 to 2015?
There has been a significant increase in OAC prescribing, particularly DOACs, among patients with T2DM in the UK between 2001 and 2015.
OBJECTIVE: To evaluate oral anticoagulant (OAC) prescribing trends in type 2 diabetes mellitus (T2DM) in the UK from 2001 to 2015. DESIGN: A cross-sectional drug utilisation study. SETTING: Electronic health records from The Health Improvement Network primary care database in the UK. PARTICIPANTS: Individuals with T2DM who received a record of OAC prescription. OUTCOME MEASURES: The prescribing trends of OAC medications in individuals with T2DM were examined from 2001 to 2015, stratified by age, gender and therapeutic classifications. RESULTS: A total of 361 635 individuals with T2DM were identified, of whom 36 570 were prescribed OAC from 2001 to 2015. The prevalence of OAC prescribing increased by 50.0%, from 1781 individuals receiving OAC prescriptions (IROACP) (4.4 (95% CI 4.2 to 4.6) per 100 persons) in 2001, to 17 070 IROACP (6.6 (95% CI 6.5 to 6.7) per 100 persons) in 2015. The prevalence of warfarin prescribing decreased by 14.0%, from 1761 individuals receiving warfarin prescriptions (IRWP) (98.9 (95% CI 98.4 to 99.4) per 100 persons) in 2001, to 14 533 IRWP (85.1 (95% CI 84.6 to 85.7) per 100 persons) in 2015. This corresponded with increased prescribing of direct oral anticoagulants (DOACs), from 18 individuals receiving DOAC prescriptions (IRDOACP) (0.1 (95% CI 0.08 to 0.23) per 100 persons) in 2010, to 3016 IRDOACP (17.6 (95% CI 17.1 to 18.2) per 100 persons) in 2015, during the same period. CONCLUSIONS: Prescribing of OACs in individuals with T2DM increased from 2001 to 2015. Since the introduction of DOACs, there has been a clear shift in prescribing towards these agents. Future studies are needed to assess the safety of coadministration of OAC medications and antidiabetic therapy with T2DM.
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Alwafi et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=361,635). Oral anticoagulants was evaluated on Prescribing trends of oral anticoagulant medications. Oral anticoagulant prescribing in individuals with type 2 diabetes increased from 4.4 per 100 persons in 2001 to 6.6 per 100 persons in 2015, with a clear shift towards direct oral anticoagulants.
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