Key result
Smoking in men with lacunar infarction is linked to ~146% higher odds of onset before 65.
Why the study?
Clinical differences in symptomatic lacunar infarction between smoking and non-smoking patients had not been studied.
Does smoking affect the clinical characteristics and 3-month recurrence rate in male patients with symptomatic lacunar infarction?
Observational (n=364)
No
Does smoking affect the clinical characteristics and 3-month recurrence rate in male patients with symptomatic lacunar infarction?
Effect estimate: OR 2.461 (95% CI 1.524-3.973)
Absolute Event Rate: 62.87% vs 35.19%
p-value: p=<0.001
In male patients with symptomatic lacunar infarction, smoking is associated with an earlier age of onset and a higher prevalence of hyperlipidemia, leukoaraiosis, and asymptomatic cerebral infarction.
Smoking cessation may warrant emphasis to potentially delay onset in at-risk men; leaves open causal effects on recurrence.
Objective: Lacunar infarction（LI） has a high prevalence and recurrence rates. Smoking is a risk factor for stroke and has a large population. At present, there are no studies on the clinical differences of symptomatic LI between patients with smoking and non-smoking. This study aimed to reveal the relationship between smoking and LI and help the treatment and primary and secondary prevention of LI. Methods: We performed a retrospective study of symptomatic LI in male patients. These patients were divided into the smoking group (SG) and non-smoking group (NSG). The variables with P<0.1 in univariate analysis were used as correction factors in multivariate logistic regression analysis. Results: We enrolled 202 smoking and 162 non-smoking male patients with symptomatic LI. Multivariate logistic regression analysis showed that the differences of SG age of onset<65Y（OR 2.461, 95%CI 1.524～3.973, P<0.001）, hyperlipidemia (OR 0.543, 95% CI0.332-0.887, P<0.05), drinking rate(OR 1.865, 95%CI 1.153-3.017, P<0.05), leukoaraiosis (OR 0.503, 95%CI 0.27-0.939, P<0.05), asymptomatic cerebral infarction (OR 0.484, 95% CI 0.276-0.846, P<0.05) and recurrence rate within 3 months of stroke (OR 2.792, 95% CI 1.014-7.691, P<0.05) were statistically significant. Conclusions: Smoking could lead to the onset age of symptomatic LI male patients significantly earlier, the prevalence of hyperlipidemia increased, accompanied by a higher drinking rate, with a higher incidence of leukoaraiosis and asymptomatic cerebral infarction. Smoking is a significant risk factor for LI. This study suggests that quitting smoking plays a vital role in the treatment and the primary and secondary prevention of LI.
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Diao et al. (2022) conducted an observational in Symptomatic Lacunar Infarction (n=364). Smoking vs. Non-smoking was evaluated on Age of onset <65 years (OR 2.461, 95% CI 1.524-3.973, p=<0.001). Smoking in male patients with symptomatic lacunar infarction was significantly associated with an earlier age of onset (<65 years) (OR 2.461) compared to non-smokers.
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