August 1, 1995Neurology
Risk factors for lacunar infarction syndromes
Key result
Hypertension (OR 8.9; 95% CI 4.2-18.8), current smoking (OR 6.6), and diabetes (OR 2.3) significantly increased the risk of lacunar stroke, while frequent physical exercise decreased the risk.
Why the study?
What are the risk factors associated with first-ever lacunar stroke?
Population
203 consecutive patients with first-ever stroke due to lacunar infarction admitted to four general hospitals…
Comparison
Exposure to risk factors including hypertension… vs Age- and sex-matched neighborhood controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports risk factor modification to reduce lacunar stroke incidence; leaves open causal mechanisms and generalizability to other populations.
Study Design
Type
Case-Control (n=203)
Multicenter
Yes
Structured PICO
What are the risk factors associated with first-ever lacunar stroke?
P
Population
203 consecutive patients with first-ever stroke due to lacunar infarction admitted to four general hospitals between 1985 and 1992, and age- and sex-matched neighborhood controls.
I
Intervention
Exposure to risk factors including hypertension, current smoking, diabetes, physical exercise, and heart disease
C
Comparator
Age- and sex-matched neighborhood controls
O
Outcome
Risk of lacunar strokehard clinical
Main Result
Effect estimate: OR 8.9 (95% CI 4.2-18.8)
Hypertension, smoking, and diabetes are strong risk factors for lacunar stroke, while physical exercise is protective, supporting a unique pathophysiologic mechanism distinct from general heart disease.
Cite This Study
You et al. (1995) conducted a case-control in Lacunar infarction (n=203). Risk factors (hypertension, smoking, diabetes, physical exercise) vs. Age- and sex-matched neighborhood controls was evaluated on Risk of lacunar stroke (hypertension) (OR 8.9, 95% CI 4.2-18.8). Hypertension (OR 8.9; 95% CI 4.2-18.8), current smoking (OR 6.6), and diabetes (OR 2.3) significantly increased the risk of lacunar stroke, while frequent physical exercise decreased the risk.