Key result
Lacunar stroke was significantly associated with hypertension, current smoking, and diabetes mellitus, and inversely associated with frequent physical exercise, but not with heart disease.
This letter discusses findings that support the lacunar hypothesis of a unique pathophysiologic mechanism for lacunar stroke driven by hypertension rather than heart disease.
To Editor: We read with interest paper by You et al [1] about risk factors for lacunar infarction in comparison with age-and sex-matched neighborhood controls. The authors found after multivariate logistic regression analysis that lacunar stroke was significantly associated with hypertension, current smoking and diabetes mellitus, and inversely associated with frequent physical exercise, but not with heart disease. They conclude that the high risk associated with hypertension but absent risk with heart disease supports `lacunar hypothesis' of a unique pathophysiologic mechanism for lacunar stroke, and furthermore, that hypertensive …
No takes yet. Share an insight, caveat, or question.
Boiten et al. (1996) conducted a letter in Lacunar infarction. Hypertension, current smoking, and diabetes mellitus vs. Age- and sex-matched neighborhood controls was evaluated on Lacunar stroke. Lacunar stroke was significantly associated with hypertension, current smoking, and diabetes mellitus, and inversely associated with frequent physical exercise, but not with heart disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: