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This research investigates how the immune system clears parasitized erythrocytes during malaria infection.

Intravascular Clearance of Parasitized Erythrocytes in Rodent Malaria

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This research investigates how the immune system clears parasitized erythrocytes during malaria infection.
Examined clearance of (51)Cr-labeled Plasmodium berghei-infected erythrocytes in rats.
Compared rates of infected erythrocyte removal between immune and control rats.
Measured splenic uptake and correlated it with spleen size.
Infected erythrocytes were cleared approximately three times faster in immune rats compared to controls.
Enhanced splenic clearance occurred during the resolution phase of malaria despite unchanged organ uptake in active infection.
Findings suggest rheologic changes in parasitized erythrocytes may drive clearance more than antibody-dependent mechanisms.

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Randomized trial examines immune response and splenic clearance of malaria-infected cells in rats, suggesting implications for malaria resolution.

Quinn et al. (1979) studied this question.

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Randomized trial examines immune response and splenic clearance of malaria-infected cells in rats, suggesting implications for malaria resolution.