What is the clinical evidence from this study?

Study design: Cohort. Population: Deep vein thrombosis (DVT) (n=343). Intervention: DVT of the upper limbs vs. DVT of the lower limbs. Primary outcome: Diagnosis of occult or undiagnosed cancer.

What question did this study set out to answer?

To compare the incidence, timing of detection, and tumor types of occult cancer in patients presenting with upper-limb versus lower-limb deep vein thrombosis.

December 1, 1999Blood Coagulation & Fibrinolysis

Venous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs

Q: What does this research mean for the field?

Upper limb deep vein thrombosis is associated with a significantly higher rate of occult cancer diagnosis during a 12-month follow-up compared to lower limb deep vein thrombosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Upper limb deep vein thrombosis was associated with a significantly higher rate of occult cancer diagnosis during a 12-month follow-up compared to lower limb DVT (23.7% vs 11.1%).

Why the study?

Is upper limb DVT more frequently associated with occult cancer compared to lower limb DVT?

Key Points

To compare the incidence, timing of detection, and tumor types of occult cancer in patients presenting with upper-limb versus lower-limb deep vein thrombosis.
Evaluated N=343 consecutive patients with deep vein thrombosis (305 lower-limb, 38 upper-limb) for undiagnosed malignancy over a 12-month follow-up period.
Cancer was diagnosed in 23.7% (9/38) of upper-limb DVT patients compared with 11.1% (34/305) of lower-limb DVT patients (statistically significant).
Seven of the nine cancers (77.8%) associated with upper-limb DVT were diagnosed during the first week of hospital admission, predominantly consisting of lung cancer and lymphomas (7/9).
In lower-limb DVT, 8 of 34 cancers were detected during the initial evaluation, exhibiting greater heterogeneity with colon and prostate cancers accounting for 12 of 34 cases.

Study Design

Type

Cohort (n=343)

Structured PICO

Is upper limb DVT more frequently associated with occult cancer compared to lower limb DVT?

Population

343 consecutive patients with deep vein thrombosis (DVT), including 305 with lower limb DVT and 38 with upper limb DVT.

Intervention

Upper limb deep vein thrombosis (DVT)

Comparator

Lower limb deep vein thrombosis (DVT)

Outcome

Diagnosis of occult or undiagnosed cancer during a 12-month follow-uphard clinical

Main Result

Absolute Event Rate: 23.7% vs 11.1%

Upper limb DVT is significantly more likely to be associated with occult cancer, particularly lung cancer and lymphomas, compared to lower limb DVT.

Discussion

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Implication

May warrant targeted cancer evaluation in upper limb DVT; hypothesis-generating and requires prospective confirmation before practice change.

Cite This Study

Girolami et al. (1999) conducted a cohort in Deep vein thrombosis (DVT) (n=343). DVT of the upper limbs vs. DVT of the lower limbs was evaluated on Diagnosis of occult or undiagnosed cancer. Upper limb deep vein thrombosis was associated with a significantly higher rate of occult cancer diagnosis during a 12-month follow-up compared to lower limb DVT (23.7% vs 11.1%).

synapsesocial.com/papers/6a12be895bb7edc7189e3610 https://doi.org/10.1097/00001721-199912000-00001

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Implication

May warrant targeted cancer evaluation in upper limb DVT; hypothesis-generating and requires prospective confirmation before practice change.

Venous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Venous thromboses of upper limbs are more frequently associated with occult cancer as compared with those of lower limbs

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider