What question did this study set out to answer?

To characterize the clinical features, onset, and chromosomal abnormalities of secondary acute nonlymphocytic leukemia in patients previously irradiated for lymphoma.

November 1, 1979Cancer

Acute non-lymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-hodgkin's lymphoma and chronic lymphocytic leukemia.Cytogenetic studies

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Authors

JWJacqueline Whang‐PengTaipei Municipal YangMing Hospital TKTor KnutsenNorwegian Institute of Marine Research HBHarmar D. BreretonInternational Medical Corps

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Implication

Cohort study reveals severe cytogenetic damage and poor survival in radiation-treated lymphoma patients developing secondary acute leukemia, indicating chromosomal loss predicts leukemic...

Key Points

To characterize the clinical features, onset, and chromosomal abnormalities of secondary acute nonlymphocytic leukemia in patients previously irradiated for lymphoma.
Evaluated a cohort of 189 patients with non-Hodgkin's lymphoma or chronic lymphocytic leukemia treated primarily with extensive radiotherapy at the National Institutes of Health Clinical Center.
Identified secondary acute nonlymphocytic leukemia or malignant myeloproliferative syndrome cases and performed serial cytogenetic analyses using chromosome banding techniques.
Eight of 189 patients developed secondary leukemia or myeloproliferative syndrome after a median latency of 61 months (range 33 to 98 months), with a median post-diagnosis survival of two months (range 0 to 9 months).
Hypodiploidy was observed across all eight patients on serial chromosome evaluations.
Chromosome 7 abnormalities occurred in 100% of banded cases (5 of 5 patients, including 4 with monosomy 7), with chromosome 5 aberrations representing the second most common defect.

Cite This Study

Whang‐Peng et al. (1979) studied this question.

synapsesocial.com/papers/6a12bec2f7bd4f5c7da6d499 https://doi.org/10.1002/1097-0142(197911)44:5<1592::aid-cncr2820440509>3.0.co;2-a

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Implication

Cohort study reveals severe cytogenetic damage and poor survival in radiation-treated lymphoma patients developing secondary acute leukemia, indicating chromosomal loss predicts leukemic...

Acute non-lymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-hodgkin's lymphoma and chronic lymphocytic leukemia.Cytogenetic studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Acute non-lymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-hodgkin's lymphoma and chronic lymphocytic leukemia.Cytogenetic studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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