Key result
Drug-eluting stents prevent restenosis but increase the risk of late stent thrombosis, which carries a 45% mortality rate and necessitates prolonged dual-antiplatelet therapy.
Population
Patients with coronary artery disease undergoing percutaneous coronary intervention
Design
Review
Authors
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Highlights need for prolonged DAPT after DES; leaves open strategies to minimize late thrombosis in future devices.
This review highlights the evolution of coronary stents, emphasizing the trade-off between reduced restenosis with DES and the increased risk of late stent thrombosis requiring prolonged dual-antiplatelet therapy.
Newsome et al. (2008) conducted a review in Coronary artery disease. Percutaneous coronary intervention (bare-metal and drug-eluting stents) was evaluated. Drug-eluting stents prevent restenosis but increase the risk of late stent thrombosis, which carries a 45% mortality rate and necessitates prolonged dual-antiplatelet therapy.
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