Key result
Familial atrial fibrillation is associated with earlier onset and worse symptoms, but all-cause mortality and thromboembolic risk are similar to non-familial atrial fibrillation.
Why the study?
Does familial atrial fibrillation have different longitudinal outcomes compared to non-familial atrial fibrillation?
Does familial atrial fibrillation have different longitudinal outcomes compared to non-familial atrial fibrillation?
Familial AF presents earlier and with worse symptoms but has similar mortality and thromboembolic risk compared to non-familial AF.
Supports equivalent anticoagulation decisions for familial versus non-familial AF; observational data leave causal and management questions open.
Several studies have suggested that family history of atrial fibrillation (AF) is an important risk factor for AF, with several specific genetic regions now implicated through Genome Wide Association Studies. In addition, familial AF is associated with earlier age of onset and affects patients with fewer comorbid conditions than their non-familial counterparts. While those with familial AF have worse symptoms, all-cause mortality and risk of thromboembolic complications are similar among familial and non-familial AF patients.
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Gundlund et al. (2017) conducted a review in Atrial fibrillation. Familial atrial fibrillation vs. Non-familial atrial fibrillation was evaluated on All-cause mortality and thromboembolic complications. Familial atrial fibrillation is associated with earlier onset and worse symptoms, but all-cause mortality and thromboembolic risk are similar to non-familial atrial fibrillation.
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