Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry
Why the study?
Does a family history of atrial fibrillation affect the age of onset, symptom severity, and clinical outcomes in patients with atrial fibrillation?
Population
9,999 patients with atrial fibrillation from 176 US outpatient clinics
Comparison
Family history of atrial fibrillation vs No family history of atrial fibrillation
Design
Cohort
Authors
Discussion
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Member takes
Overview
May warrant earlier AF evaluation in familial cases; leaves open effects on progression or survival.
Structured PICO
Does a family history of atrial fibrillation affect the age of onset, symptom severity, and clinical outcomes in patients with atrial fibrillation?
P
Population
9,999 patients with atrial fibrillation from 176 US outpatient clinics
I
Intervention
Family history of atrial fibrillation (defined as AF in a first-degree family member, obtained by patient self-reporting)
C
Comparator
No family history of atrial fibrillation
O
Outcome
Incidence of cardiovascular outcomes, AF progression, all-cause hospitalization, and all-cause deathhard clinical
A family history of atrial fibrillation is associated with earlier disease onset and greater symptom burden, but does not independently worsen long-term clinical outcomes or AF progression.
Cite This Study
Gundlund et al. (2016) studied this question.