Antiretroviral therapy exposure was associated with a significantly increased risk of coronary heart disease in HIV-infected individuals aged 18-33 years (RR 2.06; P<0.001).
Cohort (n=3,083,209)
Estimación del efecto: RR 2.06
valor p: p=<0.001
It is currently unknown whether there is an increased risk of coronary heart disease (CHD) in patients with HIV infection. In addition, the contribution of antiret-roviral therapy (ART) to CHD risk has not been quantified. We reviewed administrative claims data for HIV-infected and -uninfected individuals from the California Medicaid population and compared the incidence of and relative risk (RR) for CHD using log-linear regression analyses between groups. The association between exposure to ART and CHD incidence was also assessed. Of 3,083,209 individuals analyzed, 28,513 were HIV-infected. The incidence of CHD among young men (up to age 34) and women (up to age 44) with HIV infection was significantly higher than that among non-HIV-infected individuals. The covariate-adjusted RR for the development of CHD in individuals receiving ART compared with those not receiving ART was 2.06 (P < 0.001) in HIV-infected individuals aged 18-33 years. There were no statistically significant associations between ART exposure and CHD in other age groups. CHD incidence appears accelerated among young HIV-infected individuals. Strategies to reduce CHD risk should be incorporated into HIV primary care.
Currier et al. (Fri,) conducted a cohort in HIV infection (n=3,083,209). Antiretroviral therapy (ART) vs. No ART was evaluated on Incidence of coronary heart disease (CHD) (RR 2.06, p=<0.001). Antiretroviral therapy exposure was associated with a significantly increased risk of coronary heart disease in HIV-infected individuals aged 18-33 years (RR 2.06; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: