Key result
Higher SBP genetically correlates with lower plasma renin activity across 51 pleiotropic SNPs.
Why the study?
Genetic risk factors for blood pressure remain uncertain, and the genetic architecture of blood pressure-related traits such as renin is not fully understood.
Cohort (n=8,840)
Identified a strong negative genetic correlation and 51 pleiotropic SNPs between systolic blood pressure and plasma renin activity, providing insights into the genetic basis of the RAAS system.
Highlights RAAS genetic targets for hypertension; hypothesis-generating and requires functional validation before clinical translation.
Despite extensive studies on blood pressure, its genetic risk factors remain uncertain. Even one of the most researched blood pressure-related traits - renin - is not fully understood genetically. Here, we determine the genetic relationship and associated predisposition between blood pressure and baseline renin. In 8840 Korean individuals, we observed a strong negative genome-wide genetic correlation (rg = −0.484) between systolic blood pressure (SBP) and plasma renin activity (PRA), suggesting that antagonistic genetic signals explain the variance in the two traits. We found 51 significant pleiotropic SNPs affecting the two traits, which could contribute to the Renin-Angiotensin-Aldosterone System (RAAS). Our findings provide insight into studies on RAAS by identifying the genome-wide relationship and susceptibility loci of SBP and PRA.
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Jung et al. (2022) conducted a cohort in Systolic blood pressure and plasma renin activity (n=8,840). A strong negative genome-wide genetic correlation (rg = -0.484) was observed between systolic blood pressure and plasma renin activity in 8,840 Koreans, identifying 51 pleiotropic SNPs.
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