Key result
The AA/AG genotypes of the renin gene rs6682082 polymorphism were significantly associated with an increased risk of essential hypertension in Korean women (OR 1.493).
Why the study?
Does the A allele of the renin gene polymorphism rs6682082 increase the risk of essential hypertension and blood pressure levels in Korean women?
Case-Control (n=1,975)
Yes
Does the A allele of the renin gene polymorphism rs6682082 increase the risk of essential hypertension and blood pressure levels in Korean women?
The A allele of the rs6682082 polymorphism in the renin gene is an independent genetic risk factor for essential hypertension and elevated blood pressure in Korean women, likely mediated by increased transcriptional activation.
Supports renin polymorphism as hypertension risk factor in Korean women; leaves open replication and clinical translation.
PURPOSE: The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. MATERIALS AND METHODS: To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects. RESULTS: Logistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069-2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant. CONCLUSION: We suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.
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Park et al. (2014) conducted a case-control in Essential hypertension (n=1,975). Renin gene rs6682082 polymorphism (AA/AG genotypes) vs. GG genotype was evaluated on Risk of essential hypertension in women (OR 1.493, 95% CI 1.069-2.086, p=0.018). The AA/AG genotypes of the renin gene rs6682082 polymorphism were significantly associated with an increased risk of essential hypertension in Korean women (OR 1.493).
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