Key result
Non-pharmaceutical interventions, including alcohol septal ablation, radiofrequency catheter ablation, and gene therapy, offer effective alternatives to surgical myectomy for managing hypertrophic cardiomyopathy.
Why the study?
The review was conducted to present recent advances in non-pharmaceutical interventions for hypertrophic cardiomyopathy.
Non-pharmaceutical interventions such as alcohol septal ablation and radiofrequency catheter ablation provide effective alternatives to surgical myectomy for managing left ventricular outflow tract obstruction in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy is an inherited cardiovascular disease, and 70% of patients have left ventricular outflow tract obstruction. Ventricular septal myectomy has been the gold standard treatment for most patients with refractory symptoms. Due to higher mortality associated with medical facilities with less experience, alcohol septal ablation has been accepted as an alternative to conventional surgical myectomy. It offers lower all-cause in-hospital complications and mortality, which could be potentially more preferable for patients with serious comorbidities. In recent years, radiofrequency ablation, providing another option with reproducibility and a low risk of permanent atrioventricular block, has become an effective invasive treatment to relieve left ventricular outflow tract obstruction. Moreover, substantial progress has been made in gene therapy for hypertrophic cardiomyopathy. The principal objective of this review is to present recent advances in non-pharmaceutical interventions in hypertrophic cardiomyopathy.
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He et al. (2021) conducted a review in Hypertrophic Cardiomyopathy. Non-pharmaceutical interventions (VSM, ASA, RFCA, Gene therapy) was evaluated. Non-pharmaceutical interventions, including alcohol septal ablation, radiofrequency catheter ablation, and gene therapy, offer effective alternatives to surgical myectomy for managing hypertrophic cardiomyopathy.
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