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John H. Laragh's pioneering research on the renin-angiotensin system and the volume-vasoconstriction hypothesis revolutionized the understanding and targeted treatment of hypertension.
Highlights the historical contribution of John H. Laragh in discovering the role of renin in essential hypertension, which led to the development of ACE inhibitors and ARBs.
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Supports continued RAAS blockade in hypertension; leaves open renin-guided personalization in contemporary practice.
John Laragh is an outstanding clinician-scientist who discovered that renin, a mostly forgotten kidney hormone, causes essential hypertension1,2 and its complications.3 This discovery led to two new classes of drugs, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, which revolutionized the treatment of hypertension, cardiovascular disease, diabetes, and kidney disease and improved innumerable lives.
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Jean E. Sealey (2014) conducted an editorial in Hypertension. John H. Laragh's pioneering research on the renin-angiotensin system and the volume-vasoconstriction hypothesis revolutionized the understanding and targeted treatment of hypertension.
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