What question did this study set out to answer?

To assess the in vivo feasibility of irreversible electroporation as a drug-free, nonthermal method for controlled focal tissue ablation.

June 21, 2006IEEE Transactions on Biomedical Engineering

In Vivo Results of a New Focal Tissue Ablation Technique: Irreversible Electroporation

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To assess the in vivo feasibility of irreversible electroporation as a drug-free, nonthermal method for controlled focal tissue ablation.
Subjected the livers of male Sprague-Dawley rats to a single 20-ms square pulse of 1000 V/cm.
Assessed perfusion-fixed liver tissue histologically three hours after pulse delivery and performed mathematical analyses of electric field thresholds.
Treated tissue displayed microvascular occlusion, endothelial cell necrosis, parenchymal ischemic damage, and hepatocyte degeneration, while preserving large blood vessel architecture.
Mathematical modeling indicated that tissue destruction was primarily nonthermal, with sharp demarcation between treated and untreated tissue occurring at electric field thresholds of 300 to 500 V/cm.

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Implication

Animal study demonstrates targeted nonthermal tissue ablation via irreversible electroporation in rat liver, indicating potential for focal ablation sparing large vasculature.

Cite This Study

Edd et al. (2006) studied this question.

synapsesocial.com/papers/6a12de1016f0ac689b9e438e https://doi.org/10.1109/tbme.2006.873745

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Implication

Animal study demonstrates targeted nonthermal tissue ablation via irreversible electroporation in rat liver, indicating potential for focal ablation sparing large vasculature.

In Vivo Results of a New Focal Tissue Ablation Technique: Irreversible Electroporation

Key Points

Discussion

Implication

Cite This Study

In Vivo Results of a New Focal Tissue Ablation Technique: Irreversible Electroporation

Key Points

Discussion

Implication

Cite This Study

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