Key result
Accelerometer-derived physical activity in HF correlates weakly with KCCQ scores and 6MWD.
Why the study?
Wearable accelerometers enable continuous physical activity assessment during daily living, but their relationships with 6-minute walk distance and patient-reported functional limitation across heart failure ejection fractions needed exploration.
RCT (n=319)
Accelerometer-derived physical activity measures correlate modestly with standard functional assessments (KCCQ and 6MWD) in heart failure patients, offering complementary insights.
May complement KCCQ and 6MWD as distinct measures in heart failure; hypothesis-generating and should not yet change practice.
INTRODUCTION: Wearable accelerometers allow continuous assessment of physical activity during normal living conditions and may be useful in evaluating the effects of treatment for heart failure. We explored the relationships between accelerometer measures of physical activity and 6-minute walk distance and patient-reported measures of functional limitation in participants across the entire spectrum of left ventricular ejection fraction in the DETERMINE (Dapagliflozin EffecT on ExeRcise capacity using a 6-MINutE walk test in patients with heart failure) trials. METHODS: A subgroup of patients in the DETERMINE trials wore a waist-based accelerometer during 7-day periods at 3 points during the trial: between screening and randomization and during weeks 8 and 14. Patients completed the Kansas City Cardiomyopathy Questionnaire (KCCQ) and 6-minute walk distance (6MWD) at baseline and at weeks 8 and 16. RESULTS: Of the 817 patients randomized, 319 (39%) had adequate baseline accelerometer data. Patients with lower levels of physical activity had lower (ie, worse) KCCQ scores and 6MWD, higher NT-proBNP levels and BMIs, worse kidney function, and a greater likelihood of diabetes and atrial fibrillation. Baseline accelerometer values had weak correlations with KCCQ summary scores (Pearson r = 0.06-0.21) and weak to moderate correlations with 6MWD (Pearson r = 0.20-0.31). The change from baseline to 16 weeks in accelerometer-measured physical activity correlated weakly with the change in KCCQ summary scores (Pearson r = 0-0.18) and 6MWD (r = 0.01-0.10). CONCLUSIONS: In the DETERMINE trials, accelerometer-based measures of physical activity correlated modestly with KCCQ summary scores and 6MWD. Accelerometer-based assessments of physical activity may provide additional information complementing that obtained from standard measures of functional limitation in patients with heart failure.
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Docherty et al. (2024) conducted an RCT in Heart failure (n=319). Wearable waist-based accelerometer was evaluated on Correlation between accelerometer measures of physical activity, 6-minute walk distance (6MWD), and KCCQ scores. Wearable accelerometer-derived physical activity in heart failure patients correlated weakly with KCCQ scores (r=0.06-0.21) and weakly to moderately with 6-minute walk distance (r=0.20-0.31).
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