Why the study?
It was hypothesized that Mueller maneuvers and breath-holds would elicit greater concomitant changes in mean efferent nerve firing and BOLD signal intensity in patients with moderate to severe OSA compared with controls.
Do Mueller maneuvers and breath-holds elicit greater changes in MSNA and BOLD signal intensity in patients with moderate to severe OSA compared to those without?
Comparison
Patients with moderate to severe OSA vs age- and sex-matched individuals with no or mild OSA
Design
Physiological study with maneuvers performed in randomly assigned order
Key result
Mueller maneuvers and breath-holds elicited similar muscle sympathetic nerve activity and cortical BOLD signal responses in subjects with and without moderate to severe obstructive sleep apnea.
Authors
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Neural responses to simulated apnea are similar in OSA and controls; leaves open mechanisms of sympathetic dysregulation in sleep apnea.
Observational (n=46)
Blinded analysis
Randomized task order
No
Do Mueller maneuvers and breath-holds elicit greater changes in MSNA and BOLD signal intensity in patients with moderate to severe OSA compared to those without?
p-value: p=0.13
Recurring episodes of cyclical apnea during sleep do not appear to alter cortical or peripheral neural responsiveness to simulated apnea during wakefulness.
Taylor et al. (2021) conducted an observational in Obstructive Sleep Apnea (n=46). Mueller maneuvers and breath-holds vs. Subjects without moderate to severe OSA was evaluated on Between-group differences in muscle sympathetic nerve activity (MSNA) burst incidence during breath-holds (p=0.13). Mueller maneuvers and breath-holds elicited similar muscle sympathetic nerve activity and cortical BOLD signal responses in subjects with and without moderate to severe obstructive sleep apnea.
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