Single-unit muscle sympathetic nerve activity spike frequency was significantly correlated with sleep apnea severity (r = 0.632, p < 0.0001), with increased multiple spike firing in very severe OSAS.
Cross-Sectional (n=102)
Single-blind
No
Does single-unit muscle sympathetic nerve activity reflect sleep apnea severity in patients with obstructive sleep apnea syndrome?
Single-unit muscle sympathetic nerve activity is strongly associated with sleep apnea severity, particularly in patients with very severe obstructive sleep apnea.
Effect estimate: r = 0.632
p-value: p=<0.0001
Obstructive sleep apnea syndrome (OSAS) is associated with augmented sympathetic nerve activity, as assessed by multi-unit muscle sympathetic nerve activity (MSNA). However, it is still unclear whether single-unit MSNA is a better reflection of sleep apnea severity according to the apnea-hypopnea index (AHI). One hundred and two OSAS patients underwent full polysomnography and single- and multi-unit MSNA measurements. Univariate and multivariate regression analysis were performed to determine which parameters correlated with OSAS severity, which was defined by the AHI. Single- and multi-unit MSNA were significantly and positively correlated with AHI severity. The AHI was also significantly correlated with multi-unit MSNA burst frequency (r = 0.437, p 55. These results suggest that sympathetic nerve activity is associated with sleep apnea severity. In addition, single-unit MSNA is a more accurate reflection of sleep apnea severity with alternation of the firing pattern, especially in patients with very severe OSAS.
Hamaoka et al. (Wed,) conducted a cross-sectional in Obstructive sleep apnea syndrome (OSAS) (n=102). Single-unit muscle sympathetic nerve activity (MSNA) assessment vs. Multi-unit MSNA assessment was evaluated on Correlation between apnea-hypopnea index (AHI) and single-unit MSNA spike frequency (r = 0.632, p=<0.0001). Single-unit muscle sympathetic nerve activity spike frequency was significantly correlated with sleep apnea severity (r = 0.632, p < 0.0001), with increased multiple spike firing in very severe OSAS.