Key result
Nasal continuous positive airway pressure therapy significantly reduced muscle sympathetic nerve activity burst rate from a median of 62 to 44 bursts per minute, but did not ameliorate insulin resistance.
Why the study?
The study aimed to identify obstructive sleep apnea syndrome severity indices that reflect the anthropometric and metabolic characteristics of patients with the condition.
Does nCPAP therapy improve muscle sympathetic nerve activity and insulin resistance in patients with moderate to severe obstructive sleep apnea syndrome?
Observational (n=76)
No
Does nCPAP therapy improve muscle sympathetic nerve activity and insulin resistance in patients with moderate to severe obstructive sleep apnea syndrome?
Absolute Event Rate: 44% vs 62%
p-value: p=<0.001
In patients with OSAS, apnea/hypopnea indices correlate with glycemic control while hypoxia indices correlate with insulin resistance, and nCPAP therapy effectively reduces sympathetic nerve activity but not insulin resistance.
Should not yet alter insulin resistance management in OSAS; leaves open whether sympathetic modulation affects glycemic outcomes.
Objective We aimed to identify obstructive sleep apnea syndrome (OSAS) severity indices reflecting the anthropometric and metabolic characteristics of patients with OSAS. Methods A total of 76 patients with OSAS underwent nasal continuous positive airway pressure (nCPAP). We also investigated the effects of nCPAP on OSAS-associated muscle sympathetic nerve activity (MSNA), risk for cardiovascular diseases, and insulin secretion and sensitivity. Results Among the OSAS severity indices, HbA1c was significantly correlated with the apnea-hypopnea index, whereas HOMA-beta, HOMA-IR, and hepatic insulin resistance were significantly correlated with % SpO2<90%, independent of age, gender, and body mass index (BMI). Burst incidence of MSNA was independently associated with only a 3% oxygen desaturation index. nCPAP therapy significantly lowered the OSAS severity indices and reduced the burst rate, burst incidence, and heart rate.
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Isobe et al. (2019) conducted an observational in Obstructive sleep apnea syndrome (n=76). Nasal continuous positive airway pressure (nCPAP) vs. Baseline (pre-treatment) was evaluated on Muscle sympathetic nerve activity (MSNA) burst rate (bursts/minute) (p=<0.001). Nasal continuous positive airway pressure therapy significantly reduced muscle sympathetic nerve activity burst rate from a median of 62 to 44 bursts per minute, but did not ameliorate insulin resistance.
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